基因名：
TRAF4
产品别名：
CART1； MLN62； RNF83； TRAF4； TNF receptor associated factor 4； TNF receptor associated factor 4； TNF receptor-associated factor 4； MLN 62； RING finger protein 83； cysteine-rich domain associated with RING and Traf domains protein 1； cysteine-rich domain associated with ring and TRAF domain； malignant 62； metastatic lymph node gene 62 protein； tumor necrosis receptor-associated factor 4A； TNF受体关联因子4(TRAF4)； 肿瘤坏死因子受体相关蛋白4；
背景信息：
This gene encodes a member of the TNF receptor associated factor (TRAF) family. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. The encoded protein has been shown to interact with neurotrophin receptor, p75 (NTR/NTSR1), and negatively regulate NTR induced cell death and NF-kappa B activation. This protein has been found to bind to p47phox, a cytosolic regulatory factor included in a multi-protein complex known as NAD(P)H oxidase. This protein thus, is thought to be involved in the oxidative activation of MAPK8/JNK. Alternatively spliced transcript variants have been observed but the full-length nature of only one has been determined. [provided by RefSeq, Jul 2008].
