基因名：
RNF7
产品别名：
CKBBP1； ROC2； SAG； rbx2； RNF7； ring finger protein 7； ring finger protein 7； RING-box protein 2； CKII beta-binding protein 1； regulator of cullins 2； sensitive to apoptosis gene protein； sensitive to apoptosis zinc RING finger protein SAG； sensitive to apoptosis, zinc RING finger protein SAG, regulator of cullins 2； zinc RING finger protein SAG； 环指蛋白7；
背景信息：
Probable component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate. Promotes the neddylation of CUL5 via its interaction with UBE2F. May play a role in protecting cells from apoptosis induced by redox agents. Tissue specificity: Expressed in heart, liver, skeletal muscle and pancreas. At very low levels expressed in brain, placenta and lung.
