基因名：
IL27RA
产品别名：
CRL1； IL-27RA； IL27R； TCCR； WSX1； zcytor1； IL27RA； interleukin 27 receptor subunit alpha； interleukin 27 receptor subunit alpha； interleukin-27 receptor subunit alpha； IL-27 receptor subunit alpha； IL-27R subunit alpha； IL-27R-alpha； T-cell cytokine receptor type 1； class I cytokine receptor； cytokine receptor WSX-1； cytokine receptor-like 1； interleukin 27 receptor, alpha； type I T-cell cytokine receptor； IL27RA蛋白； 白介素27受体α(IL27Ra)； 白细胞介素27受体；
背景信息：
Upon antigen challenge, T-helper cells differentiate into two functionally distinct subsets, Th1 and Th2. Th1 cells produce IL-2, IFN-gamma and lymphotoxin-b that augment the cell-mediated immune response, while Th2 cells secrete IL-4, IL-5, and IL-10 that enhance humoral immunity. The function of T-helper cells is regulated by cytokines. A novel cytokine receptor was recently identified and cloned. It is a new member in the type I cytokine receptor family and designated TCCR for T-cell cytokine receptor and WSX-1. TCCR deficient mice had impaired Th1 responses to protein antigen challenge, including decreased levels of IFN-gamma and Th1-dependent antibody IgG2a. TCCR is predominantly expressed in thymus, spleen, lymph nodes and peripheral blood leukocytes.
