基因名：
MED7
产品别名：
ARC34； CRSP33； CRSP9； MED7； mediator complex subunit 7； mediator complex subunit 7； mediator of RNA polymerase II transcription subunit 7； CRSP complex subunit 9； RNA polymerase transcriptional regulation mediator subunit 7 homolog； activator-recruited cofactor 34 kDa component； cofactor required for Sp1 transcriptional activation subunit 9； cofactor required for Sp1 transcriptional activation, subunit 9 (33kD)； cofactor required for Sp1 transcriptional activation, subunit 9, 33kDa； transcriptional coactivator CRSP33； 转录激活蛋白CRSP9；
背景信息：
In mammalian cells, transcription is regulated in part by high molecular weight coactivating complexes that mediate signals between transcriptional activators and RNA polymerase (1). These complexes include the SMCC (SRB and MED protein cofactor complex), which consists of various subunits that share homology with several components of the yeast transcriptional mediator complexes, and including the human proteins Srb7, Med6 (also designated DRIP33) and Med7 (also designated DRIP34) (2,3). SMCC associates with the RNAPII (RNA polymerase II) holoenzyme through Srb7 and, in turn, enhances gene-specific activation or repression induced by DNA-binding transcription factors (4). Med6 and Med7, as well as other components of SMCC, associate with coactivator proteins from the TRAP (thyroid hormone receptor-activating protein) complex and DRIP (for vitamin D receptor interacting protein) complex to facilitate steroid receptor dependent transcriptional activation (4,5). Additionally, SMCC associates with PC4 (positive cofactor 4) to repress basal transcription independent of RNAPII activity (6).
