基因名:
ASIC3
产品别名:
ACCN3; DRASIC; SLNAC1; TNaC1; ASIC3; acid sensing ion channel subunit 3; acid sensing ion channel subunit 3; acid-sensing ion channel 3; acid sensing (proton gated) ion channel 3; amiloride-sensitive cation channel 3, testis; modulatory subunit of ASIC2a; neuronal amiloride-sensitive cation channel 3; proton-gated cation channel subunit; testis sodium channel 1; 酸敏感离子通道蛋白3;
背景信息:
Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Generates a biphasic current with a fast inactivating and a slow sustained phase. In sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic, damaged or inflamed tissue. May be involved in hyperalgesia. May play a role in mechanoreception. Heteromeric channel assembly seems to modulate channel properties.