基因名：
RPS6KA5
产品别名：
MSK1； MSPK1； RLPK； RPS6KA5； ribosomal protein S6 kinase A5； ribosomal protein S6 kinase A5； ribosomal protein S6 kinase alpha-5； 90 kDa ribosomal protein S6 kinase 5； RSK-like protein kinase； RSKL； S6K-alpha-5； nuclear mitogen- and stress-activated protein kinase 1； ribosomal protein S6 kinase, 90kDa, polypeptide 5； 有丝分裂原和应激活化型蛋白激酶1； 核糖体蛋白S6激酶α5(RPS6Ka5)； 磷酸化有丝分裂原和应激活化型蛋白激酶1；
背景信息：
MSK1 is a mitogen and stress activated protein kinase 1 which belongs to the AGC family of kinases and is related in structure to the ribosomal p70 S6 kinase subfamily. MSK1 can be activated by ERK1/2 and SAPK2/p38 MAP kinase. It is also known to be required for the phosphorylation of CREB, ATF1 H3 and HMG14 in response to mitogen and stress. Similar to RSK, MSK1 contains two kinase domains (N term and a C term). Once phosphorylated on Thr581 and Ser360 by ERK1/2 and SAPK2/p38, MSK1 autophosphorylate on at least 5 sites. Of these autophosphorylation sites Ser212 and Ser376 get phosphorylated by the C terminal kinase domain of MSK1 which is essential for the catalytic activity of the N terminal kinase domain.
