基因名：
LRRFIP1
产品别名：
FLAP-1； FLAP1； FLIIAP1； GCF-2； GCF2； HUFI-1； TRIP； LRRFIP1； LRR binding FLII interacting protein 1； LRR binding FLII interacting protein 1； leucine-rich repeat flightless-interacting protein 1； GC-binding factor 2； LRR FLII-interacting protein 1； NEDD8-conjugating enzyme； TAR RNA-interacting protein； leucine rich repeat (in FLII) interacting protein 1； 亮氨酸丰富重复FLII相互作用蛋白1(LRRFIP1)； 巨噬细胞调控相关蛋白LRRFIP1；
背景信息：
LRRFIP1 is an 738 amino acid human protein whose rodent counterpart is known as Lrrfip1 (also designated FLAP in mouse). LRRFIP1 is also believed to control smooth muscle cell proliferation following arterial injury through PDGF-A repression. The N-terminus of LRRFIP1 shows high homology to the coiled-coil domain of FLAP, a protein which binds the leucine-rich repeat (LRR) of Flightless I, and the interaction of LRRFIP1 with the LRR of Flightless I has been confirmed. LRRFIP1 does not bind single-stranded DNA or RNA significantly and binds double-stranded DNA weakly. In contrast, LRRFIP1 binds double-stranded RNA with high affinity, and two molecules of LRRFIP1 bind the TaR stem. The RNA binding domain has been identified and encompasses a lysine-rich motif. Flightless I has a C-terminal TaR-like domain which binds Actin and therefore the association of LRRFIP1 with the LRR of Flightless I may provide a link between the Actin cytoskeleton and RNA in mammalian cells.
