基因名：
AIFM1
产品别名：
AIF； AUNX1； CMT2D； CMTX4； COWCK； COXPD6； DFNX5； NADMR； NAMSD； PDCD8； SEMDHL； AIFM1； apoptosis inducing factor mitochondria associated 1； apoptosis inducing factor mitochondria associated 1； apoptosis-inducing factor 1, mitochondrial； apoptosis-inducing factor, mitochondrion-associated, 1； auditory neuropathy, X-linked recessive 1； programmed cell death 8 (apoptosis-inducing factor)； striatal apoptosis-inducing factor； testicular secretory protein Li 4； 凋亡诱导因子(AIF)； 调亡诱导因子；
背景信息：
Apoptosis-Inducing Factor 1, Mitochondrial (AIFM1) is a flavoprotein essential for nuclear disassembly in apoptotic cells that is found in the mitochondrial intermembrane space in healthy cells. During apoptosis, it is translocated from the mitochondria to the nucleus to function as a proapoptotic factor in a caspase-independent pathway, while in normal mitochondria, it functions as an antiapoptotic factor via its oxidoreductase activity. The soluble form (AIFsol) found in the nucleus induces parthanatos i.e., caspase-independent fragmentation of chromosomal DNA. AIFM1 interacts with EIF3G, and thereby inhibits the EIF3 machinery and protein synthesis, and activates casapse-7 to amplify apoptosis. It binds to DNA in a sequence-independent manner and plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells.
