基因名：
DIRAS3
产品别名：
ARHI； NOEY2； DIRAS3； DIRAS family GTPase 3； DIRAS family GTPase 3； GTP-binding protein Di-Ras3； DIRAS family, GTP-binding RAS-like 3； distinct subgroup of the Ras family member 3； ras homolog gene family, member I； rho-related GTP-binding protein RhoI； 抑癌基因ras同源家族1；
背景信息：
ARHI contains a highly conserved GTP-binding domain, a putative effector domain distinct from that of RAS and RAP proteins, and a C-terminal membrane localization motif. ARHI mRNA is detected in all normal breast and ovarian epithelial cell cultures tested, as well as in normal ovary, heart, liver, pancreas and brain however ARHI expression is down-regulated in breast and ovarian tumors. Reactivation of ARHI expression in breast cancer cells is associated with increased histone H3 acetylation and decreased lysine 9 methylation of histone H3.
