基因名:
MCM3AP
产品别名:
GANP; MAP80; PNRIID; SAC3; MCM3AP; minichromosome maintenance complex component 3 associated protein; minichromosome maintenance complex component 3 associated protein; germinal-center associated nuclear protein; 80 kDa MCM3-associated protein; MCM3 acetylating protein; MCM3 acetyltransferase; MCM3 import protein; MCM3 minichromosome maintenance deficient 3 associated protein; germinal center-associated nuclear protein; germinal-centre associated nuclear protein; 微小染色体维持缺陷蛋白3关联蛋白(MCM3AP); 生发中心相关核蛋白MCM3;
背景信息:
The minichromosome maintenance protein 3 (MCM3) is one of the MCM proteins essential for the initiation of DNA replication. The protein encoded by this gene is a MCM3 binding protein. It was reported to have phosphorylation-dependent DNA-primase activity, which was up-regulated in antigen immunization induced germinal center. This protein was demonstrated to be an acetyltransferase that acetylates MCM3 and plays a role in DNA replication. The mutagenesis of a nuclear localization signal of MCM3 affects the binding of this protein with MCM3, suggesting that this protein may also facilitate MCM3 nuclear localization.