基因名：
TNFRSF10B
产品别名：
CD262； DR5； KILLER； KILLER/DR5； TRAIL-R2； TRAILR2； TRICK2； TRICK2A； TRICK2B； TRICKB； ZTNFR9； TNFRSF10B； TNF receptor superfamily member 10b； TNF receptor superfamily member 10b； tumor necrosis factor receptor superfamily member 10B； Fas-like protein； TNF-related apoptosis-inducing ligand receptor 2； apoptosis inducing protein TRICK2A/2B； apoptosis inducing receptor TRAIL-R2； cytotoxic TRAIL receptor-2； death domain containing receptor for TRAIL/Apo-2L； death receptor 5； p53-regulated DNA damage-inducible cell death receptor(killer)； tumor necrosis factor receptor superfamily, member 10b； tumor necrosis factor receptor-like protein ZTNFR9； DR4蛋白； DR5蛋白； 死亡受体5； 死亡受体5(DR5)； 肿瘤细胞调亡素/死亡受体5；
背景信息：
TNFRSF10B is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces apoptosis signal. The adapter molecule FADD recruits caspase-8 to the activated receptor and is required for the apoptosis mediated by TNFRSF10B. TNFRSF10B is expressed in a number of cell types, and to particularly high levels in lymphocytes and spleen. This single-pass transmembrane protein contains two cysteine-rich repeat units in its extracellular region, followed by a transmembrane segment and a cytoplasmic tail containing a typical 'death domain'. TNFRSF10B expression is regulated by the tumor suppressor p53. It is also indicated that the activation of NF-kappa-B can be promoted by TNFRSF10B.
