基因名：
UCHL1
产品别名：
HEL-117； HEL-S-53； NDGOA； PARK5； PGP 9.5； PGP9.5； PGP95； SPG79； UCHL-1； Uch-L1； UCHL1； ubiquitin C-terminal hydrolase L1； ubiquitin C-terminal hydrolase L1； ubiquitin carboxyl-terminal hydrolase isozyme L1； epididymis luminal protein 117； epididymis secretory protein Li 53； neuron cytoplasmic protein 9.5； ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)； ubiquitin thioesterase L1； ubiquitin thiolesterase； 泛素硫酯酶L1+3； 泛素羧基端酯酶L1(UCHL1)； 神经细胞胞浆蛋白9.5/蛋白基因产物9.5； 神经细胞胞浆蛋白9.5蛋白；
背景信息：
Ubiquitin Carboxyl-Terminal Hydrolase Isozyme L1 (UCHL1) belongs to the Peptidase C12 family. UCHL1 is specifically expressed in the neurons and in cells of the diffuse neuroendocrine system. UCHL1 is a component of the ubiquitin system, which has a fundamental role in regulating various biological activities. UCHL1 is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. UCHL1 also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer of UCHL1 may have ATP-independent ubiquitin ligase activity.
