基因名：
UBE2H
产品别名：
E2-20K； GID3； UBC8； UBCH； UBCH2； UBE2H； ubiquitin conjugating enzyme E2 H； ubiquitin conjugating enzyme E2 H； ubiquitin-conjugating enzyme E2 H； (E3-independent) E2 ubiquitin-conjugating enzyme H； E2 ubiquitin-conjugating enzyme H； GID complex subunit 3, UBC8 homolog； ubiquitin carrier protein H； ubiquitin conjugating enzyme E2H； ubiquitin-conjugating enzyme E2-20K； ubiquitin-conjugating enzyme E2H (UBC8 homolog, yeast)； ubiquitin-conjugating enzyme E2H (homologous to yeast UBC8)； ubiquitin-protein ligase H； 泛素激活酶2H；
背景信息：
Ubiquitin-Conjugating Enzyme E2 H (UBE2H) belongs to the E2 Ubiquitin-Conjugating Enzyme family. The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. It has been shown to conjugate ubiquitin to histone H2A in an E3 dependent manner in vitro. UBE2H is the human homolog to the yeast DNA repair gene RAD6, which is induced by DNA damaging reagents. UBE2H has been associated with cancer-induced cachexia and with the regulation of sepsis-induced muscle proteolysis.
