基因名：
UBA7
产品别名：
D8； UBA1B； UBE1L； UBE2； UBE7； UBA7； ubiquitin like modifier activating enzyme 7； ubiquitin like modifier activating enzyme 7； ubiquitin-like modifier-activating enzyme 7； UBA1, ubiquitin-activating enzyme E1 homolog B； UBA7, ubiquitin-activating enzyme E1； ubiquitin-activating enzyme 7； ubiquitin-activating enzyme E1 homolog； ubiquitin-activating enzyme E1-related protein； ubiquitin-activating enzyme-2； 泛素激活酶2/泛素激活酶E1相关蛋白； 泛素激活酶样蛋白(UBE1L)；
背景信息：
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme is a retinoid target that triggers promyelocytic leukemia (PML)/retinoic acid receptor alpha (RARalpha) degradation and apoptosis in acute promyelocytic leukemia, where it is involved in the conjugation of the ubiquitin-like interferon-stimulated gene 15 protein. [provided by RefSeq, Jul 2008].
