基因名：
HIRA
产品别名：
DGCR1； TUP1； TUPLE1； HIRA； histone cell cycle regulator； histone cell cycle regulator； protein HIRA； DiGeorge critical region gene 1； HIR histone cell cycle regulation defective homolog A； TUP1-like enhancer of split protein 1； histone regulator A； 磷酸化HIRA蛋白； 组蛋白替换精蛋白DGGR1；
背景信息：
This gene encodes a histone chaperone that preferentially places the variant histone H3.3 in nucleosomes. Orthologs of this gene in yeast, flies, and plants are necessary for the formation of transcriptionally silent heterochomatin. This gene plays an important role in the formation of the senescence-associated heterochromatin foci. These foci likely mediate the irreversible cell cycle changes that occur in senescent cells. It is considered the primary candidate gene in some haploinsufficiency syndromes such as DiGeorge syndrome, and insufficient production of the gene may disrupt normal embryonic development. [provided by RefSeq, Jul 2008]
