基因名：
TRAF6
产品别名：
MGC:3310； RNF85； TRAF6； TNF receptor associated factor 6； TNF receptor associated factor 6； TNF receptor-associated factor 6； E3 ubiquitin-protein ligase TRAF6； RING finger protein 85； RING-type E3 ubiquitin transferase TRAF6； TNF receptor-associated factor 6, E3 ubiquitin protein ligase； interleukin-1 signal transducer； TNF受体关联因子6(TRAF6)； 肿瘤坏死因子受体相关因子6；
背景信息：
The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. This protein mediates the signaling not only from the members of the TNF receptor superfamily, but also from the members of the Toll/IL-1 family. Signals from receptors such as CD40, TNFSF11/RANCE and IL-1 have been shown to be mediated by this protein. This protein also interacts with various protein kinases including IRAK1/IRAK, SRC and PKCzeta, which provides a link between distinct signaling pathways. This protein functions as a signal transducer in the NF-kappaB pathway that activates IkappaB kinase (IKK) in response to proinflammatory cytokines. The interaction of this protein with UBE2N/UBC13, and UBE2V1/UEV1A, which are ubiquitin conjugating enzymes catalyzing the formation of polyubiquitin chains, has been found to be required for IKK activation by this protein. Two alternatively spliced transcript variants encoding identical proteins have been reported. [provided by RefSeq].
