基因名：
TPTE
产品别名：
CT44； PTEN2； TPTE； transmembrane phosphatase with tensin homology； transmembrane phosphatase with tensin homology； putative tyrosine-protein phosphatase TPTE； PTEN-related tyrosine phosphatase； cancer/testis antigen 44； tensin, putative protein-tyrosine phosphatase； tumor antigen BJ-HCC-5； 肿瘤/睾丸抗原44；
背景信息：
TPTE is a 551 amino acid multi-pass membrane protein belonging to the PTEN-related family that is exclusively expressed in the testis and localizes to the plasma membrane in humans. The gene encoding TPTE is present in multiple copies in the human genome, some of which may be pseudogenes. TPTE contains one C2 tensin-type domain and one phosphatase tensin-type domain but, in humans, it does not exhibit phosphatase activity. However, the mouse ortholog (PTEN2) is a functional 3-phosphoinositide phosphatase that localizes to the Golgi apparatus and plays a possible role in signal transduction. In humans, four isoforms, namely TPTEå, TPTE∫, TPTE© and TPTE∂, are produced by alternative splicing of this gene.
