基因名：
TPBG
产品别名：
5T4； 5T4AG； M6P1； WAIF1； TPBG； trophoblast glycoprotein； trophoblast glycoprotein； trophoblast glycoprotein； 5T4 oncofetal antigen； 5T4 oncofetal trophoblast glycoprotein； 5T4 oncotrophoblast glycoprotein； wnt-activated inhibitory factor 1； 滋养层特异性糖蛋白； 滋养层特异性糖蛋白真核蛋白； 滋养层细胞糖蛋白5T4；
背景信息：
Trophoblast glycoprotein, also known as TPBG and 5T4, it belongs to the LRR family of proteins. The C-terminus of LRR N-terminal cap (LRRNT) and LRR 1 are essential for the inhibition of the Wnt signaling pathway. TPBG may function as an inhibitor of Wnt/beta-catenin signaling by indirectly interacting with LRP6 and blocking Wnt3a-dependent LRP6 internalization. It expressed by all types of trophoblasts as early as 9 weeks of development. In adult tissues, the expression is limited to a few epithelial cell types but is found on a variety of carcinoma.
