基因名：
KLF10
产品别名：
EGR-alpha； EGRA； TIEG； TIEG1； KLF10； KLF transcription factor 10； KLF transcription factor 10； Krueppel-like factor 10； Kruppel like factor 10； TGFB-inducible early growth response protein 1； early growth response-alpha； transforming growth factor-beta-inducible early growth response protein 1； zinc finger transcription factor TIEG； TGF-β诱导早期应答基因1； TGFβ诱导早期应答基因1(TIEG1)；
背景信息：
KLF10 is a transcription factor that plays a role in the regulation of cell growth. It binds to the consensus sequence 5'-GGTGTG-3'. KLF10 plays a role in the response to TGFbeta (through the TGFbeta/Smad signalling pathway) and estrogen. In both cases, KLF10 induces or repressed gene transcription to enhance the TGFbeta/Smad signalling pathway, as well as other pathways, to regulate cell proliferation, differentiation and apoptosis. KLF10 has been shown to have a role in skeletal disease (osteopenia/osteoporosis), hypertrophic cardiomyopathy, and breast and prostate cancer.
