基因名:
NR2F1
产品别名:
BBOAS; BBSOAS; COUP-TFI; COUPTF1; EAR-3; EAR3; ERBAL3; SVP44; TCFCOUP1; TFCOUP1; NR2F1; nuclear receptor subfamily 2 group F member 1; nuclear receptor subfamily 2 group F member 1; COUP transcription factor 1; COUP transcription factor I; COUP-TF I; COUP-TF1; V-erbA-related protein 3; chicken ovalbumin upstream promoter-transcription factor I; transcription factor COUP 1 (chicken ovalbumin upstream promoter 1, v-erb-a homolog-like 3); 转录因子COUP1;
背景信息:
COUP transcription factors have been cloned in several species and identified as orphan members of the steroid/thyroid hormone receptor superfamily. COUP-TFI (also designated COUP or EAR-3) and ARP-1 (also designated COUP-TFII) exhibit highly regulated and overlapping expression in most tissues. COUP-TFs are highly expressed in the developing and central nervous system, suggesting that these factors may be important in neural development and differentiation. COUP-TFs can compete for binding to response elements which are common to other members of this family, including RAR, RXR, PPAR, HNF-4, VDR and TR. They have been shown to act as negative regulators as well as initiators of transcription.