基因名:
HNF1A
产品别名:
HNF-1-alpha; HNF-1A; HNF1; HNF1alpha; HNF4A; IDDM20; LFB1; MODY3; TCF-1; TCF1; HNF1A; HNF1 homeobox A; HNF1 homeobox A; hepatocyte nuclear factor 1-alpha; albumin proximal factor; hepatic nuclear factor 1; interferon production regulator factor; liver-specific transcription factor LF-B1; transcription factor 1, hepatic; 肝细胞核因子1α; 肝细胞核因子1α(HNF1a);
背景信息:
IRF1 encodes interferon regulatory factor 1, a member of the interferon regulatory transcription factor (IRF) family. IRF1 serves as an activator of interferons alpha and beta transcription, and in mouse it has been shown to be required for double-stranded RNA induction of these genes. IRF1 also functions as a transcription activator of genes induced by interferons alpha, beta, and gamma. Further, IRF1 has been shown to play roles in regulating apoptosis and tumor-suppressoion.