基因名：
STAT5A
产品别名：
MGF； STAT5； STAT5A； signal transducer and activator of transcription 5A； signal transducer and activator of transcription 5A； signal transducer and activator of transcription 5A； epididymis secretory sperm binding protein； 信号传导转录激活因子5A(STAT5A)； 信号转导和转录激活因子5； 磷酸化信号转导和转录激活因子5a；
背景信息：
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for the tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells. [provided by RefSeq, Jul 2008]
