基因名：
TRIM21
产品别名：
RNF81； RO52； Ro/SSA； SSA； SSA1； TRIM21； tripartite motif containing 21； tripartite motif containing 21； E3 ubiquitin-protein ligase TRIM21； 52 kDa Ro protein； 52 kDa ribonucleoprotein autoantigen Ro/SS-A； RING finger protein 81； RING-type E3 ubiquitin transferase TRIM21； Ro/SSA 52kDa； SS-A； Sicca syndrome antigen A； Sjogren syndrome antigen A1 (52kDa, ribonucleoprotein autoantigen SS-A/Ro)； ro(SS-A)； sjoegren syndrome type A antigen； tripartite motif-containing protein 21； 核糖核蛋白自身抗原；
背景信息：
This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The encoded protein is part of the RoSSA ribonucleoprotein, which includes a single polypeptide and one of four small RNA molecules. The RoSSA particle localizes to both the cytoplasm and the nucleus. RoSSA interacts with autoantigens in patients with Sjogren syndrome and systemic lupus erythematosus. Alternatively spliced transcript variants for this gene have been described but the full-length nature of only one has been determined. [provided by RefSeq, Jul 2008].
