基因名:
SLC1A2
产品别名:
DEE41; EAAT2; EIEE41; GLT-1; GLT1; HBGT; SLC1A2; solute carrier family 1 member 2; solute carrier family 1 member 2; excitatory amino acid transporter 2; excitotoxic amino acid transporter 2; glutamate transporter-1; glutamate/aspartate transporter II; human brain glutamate transporter; sodium-dependent glutamate/aspartate transporter 2; solute carrier family 1 (glial high affinity glutamate transporter), member 2; 兴奋性氨基酸转运蛋白2(EAAT2); 胶质细胞谷氨酸运载蛋白2;
背景信息:
This gene encodes a member of a family of solute transporter proteins. The membrane-bound protein is the principal transporter that clears the excitatory neurotransmitter glutamate from the extracellular space at synapses in the central nervous system. Glutamate clearance is necessary for proper synaptic activation and to prevent neuronal damage from excessive activation of glutamate receptors. Mutations in and decreased expression of this protein are associated with amyotrophic lateral sclerosis. Alternatively spliced transcript variants of this gene have been identified. [provided by RefSeq, Sep 2010]