基因名：
MAP2K4
产品别名：
JNKK； JNKK1； MAPKK4； MEK4； MKK4； PRKMK4； SAPKK-1； SAPKK1； SEK1； SERK1； SKK1； MAP2K4； mitogen-activated protein kinase kinase 4； mitogen-activated protein kinase kinase 4； dual specificity mitogen-activated protein kinase kinase 4； JNK-activated kinase 1； JNK-activating kinase 1； MAP kinase kinase 4； MAPK/ERK kinase 4； MAPKK 4； MEK 4； SAPK/ERK kinase 1； c-Jun N-terminal kinase kinase 1； stress-activated protein kinase kinase 1； 丝裂原活化蛋白激酶激酶4； 丝裂原激活蛋白激酶激酶4(MAP2K4)； 磷酸化丝裂原活化蛋白激酶激酶4；
背景信息：
This gene encodes a member of the mitogen-activated protein kinase (MAPK) family. Members of this family act as an integration point for multiple biochemical signals and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. They form a three-tiered signaling module composed of MAPKKKs, MAPKKs, and MAPKs. This protein is phosphorylated at serine and threonine residues by MAPKKKs and subsequently phosphorylates downstream MAPK targets at threonine and tyrosine residues. A similar protein in mouse has been reported to play a role in liver organogenesis. A pseudogene of this gene is located on the long arm of chromosome X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
