基因名：
SEL1L
产品别名：
Hrd3； PRO1063； SEL1-LIKE； SEL1L1； SEL1L； SEL1L adaptor subunit of ERAD E3 ubiquitin ligase； SEL1L adaptor subunit of ERAD E3 ubiquitin ligase； protein sel-1 homolog 1； SEL1L, ERAD E3 ligase adaptor subunit； Suppressor of lin 12 (sel-1), C. elegans, homolog of； sel-1 suppressor of lin-12-like 1； suppressor of lin-12-like protein 1；
背景信息：
SEL1L, highly similar to the C elegans sel-1 gene, is a recently cloned human gene whose function is under investigation. SEL1L is differentially expressed in tumors and normal tissues and seems to play a role in tumor growth and aggressiveness. It may be an important negative regulator of the "notch" pathway which acts as a key regulator of the cellular proliferation and specification processes in both vertebrates and invertebrates. SEL1L may function in the protein degradation processes through the ubiquitin-proteosome system and perhaps in regulating important pathways such TGF-beta.
It is ubiquitously expressed only in fetal and neoplastic tissues. In normal adult tissues is highly expressed in the acini and in the alpha cells of the pancreas; in general it is highly represented in secretory cells such as plasma cells.
