基因名：
CCL13
产品别名：
CKb10； MCP-4； NCC-1； NCC1； SCYA13； SCYL1； CCL13； C-C motif chemokine ligand 13； C-C motif chemokine ligand 13； C-C motif chemokine 13； CK-beta-10； chemokine (C-C motif) ligand 13； monocyte chemoattractant protein 4； monocyte chemotactic protein 4； new CC chemokine 1； small inducible cytokine subfamily A (Cys-Cys), member 13； small-inducible cytokine A13； 单核细胞趋化蛋白4； 单核细胞趋化蛋白4(MCP4)； 单核细胞趋化蛋白4(MCP4)真核蛋白；
背景信息：
Monocyte Chemoattractant Proteins 4 (MCP-4/CCL13) is a member of a distinct, structurally-related subclass of CC chemokines mainly involved in recruitment of eosinphils to inflammatory sites. CCL13/MCP-4, is a CC family chemokine that is chemoattractant for eosinophils, basophils, monocytes, macrophages, immature dendritic cells, and T cells, and its capable of inducing crucial immuno-modulatory responses through its effects on epithelial, muscular and endothelial cells. Similar to other CC chemokines, CCL13 binds to several chemokine receptors (CCR1, CCR2 and CCR3), allowing it to elicit different effects on its target cells. A number of studies have shown that CCL13 is involved in many chronic inflammatory diseases, in which it functions as a pivotal molecule involved in the selective recruitment of cell lineages to the inflamed tissues and their subsequent activation. MCP-4/CCL13 is secreted from chondrocytes and activates the proliferation of rheumatoid synovial cells, thereby leading to joint destruction in RA.
