基因名：
MAPK12
产品别名：
ERK-6； ERK3； ERK6； MAPK 12； P38GAMMA； PRKM12； SAPK-3； SAPK3； MAPK12； mitogen-activated protein kinase 12； mitogen-activated protein kinase 12； mitogen-activated protein kinase 12； MAP kinase 12； MAP kinase p38 gamma； extracellular signal-regulated kinase 6； mitogen-activated protein kinase 3； mitogen-activated protein kinase p38 gamma； stress-activated protein kinase 3； 丝裂原活化蛋白激酶磷酸酶p38γ； 丝裂原激活蛋白激酶12(MAPK12)； 磷酸化丝裂原活化蛋白激酶磷酸酶p38γ；
背景信息：
MAP (mitogen-activated protein) kinases play a significant role in many biological processes, including cell adhesion and spreading, cell differentiation and apoptosis. p38 alpha, p38 beta and p38 gamma, also known as MAPK14, MAPK11 and MAPK12, respectively, each contain one protein kinase domain and belong to the MAP kinase family. Expressed in different areas throughout the body with common expression patterns in heart, p38 proteins use magnesium as a cofactor to catalyze the ATP-dependent phosphorylation of target proteins. Via their catalytic activity, p38 alpha, p38 beta and p38 gamma are involved in a variety of events throughout the cell, including signal transduction pathways, cytokine production and cell proliferation and differentiation. The p38 proteins are subject to phosphoryation on Thr and Tyr residues, an event which is thought to activate the phosphorylated protein.
