基因名：
PTPRN2
产品别名：
IA-2beta； IAR； ICAAR； PTPRP； R-PTP-N2； PTPRN2； protein tyrosine phosphatase receptor type N2； protein tyrosine phosphatase receptor type N2； receptor-type tyrosine-protein phosphatase N2； IAR/receptor-like protein-tyrosine phosphatase； islet cell autoantigen-related protein； phogrin； protein tyrosine phosphatase receptor pi； protein tyrosine phosphatase, receptor type, N polypeptide 2； tyrosine phosphatase IA-2 beta； 胰岛细胞自身抗原相关蛋白PTPRN2； 蛋白酪氨酸磷酸酶受体N2(PTPRN2)；
背景信息：
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracellular catalytic domain, and thus represents a receptor-type PTP. The catalytic domain of this PTP is most closely related to PTPRN/IA-2beta. This PTP and PTPRN are both found to be major autoantigens associated with insulin-dependent diabetes mellitus. Three alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]
