基因名：
PTPN6
产品别名：
HCP； HCPH； HPTP1C； PTP-1C； SH-PTP1； SHP-1； SHP-1L； SHP1； PTPN6； protein tyrosine phosphatase non-receptor type 6； protein tyrosine phosphatase non-receptor type 6； tyrosine-protein phosphatase non-receptor type 6； hematopoietic cell phosphatase； hematopoietic cell protein-tyrosine phosphatase； protein-tyrosine phosphatase 1C； protein-tyrosine phosphatase SHP-1； 磷酸化蛋白酪氨酸磷酸酶1C； 蛋白酪氨酸磷酸酶1C； 造血细胞磷酸酶； 非受体型蛋白酪氨酸磷酸酶6(PTPN6)；
背景信息：
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jul 2008]
