基因名：
PRKAR2A
产品别名：
PKR2； PRKAR2； PRKAR2A； protein kinase cAMP-dependent type II regulatory subunit alpha； protein kinase cAMP-dependent type II regulatory subunit alpha； cAMP-dependent protein kinase type II-alpha regulatory subunit； cAMP-dependent protein kinase regulatory subunit RII alpha； protein kinase A, RII-alpha subunit； protein kinase, cAMP-dependent, regulatory subunit type II alpha； 磷酸化蛋白激酶A受体2α亚基； 蛋白激酶A受体2α亚基；
背景信息：
The second messenger cyclic AMP (cAMP) mediates diverse cellular responses to external signals such as proliferation, ion transport, regulation of metabolism and gene transcription by activation of the cAMP-dependent protein kinase (cAPK or PKA). Activation of PKA occurs when cAMP binds to the two regulatory subunits of the tetrameric PKA holoenzyme, resulting in release of active catalytic subunits. Activation of transcription upon elevation of cAMP levels results from translocation of PKA to the nucleus, where it phosphorylates the transcription factor cAMP response element binding protein (CREB) on Serine 133, which in turn leads to TFIIB binding to TATA-box-binding protein TBP1, thus linking phospho-CREB to the Pol II transcription initiation complex. Mouse Serine 96 (designated Ser 99 in human) is a phosphorylation site on the PKA II?regulatory subunit
