基因名：
PRKAB2
产品别名：
PRKAB2； protein kinase AMP-activated non-catalytic subunit beta 2； protein kinase AMP-activated non-catalytic subunit beta 2； 5'-AMP-activated protein kinase subunit beta-2； 5'-AMP-activated protein kinase, beta-2 subunit； AMP-activated protein kinase beta 2 non-catalytic subunit； AMPK beta 2； AMPK beta-2 chain； AMPK subunit beta-2； protein kinase, AMP-activated, beta 2 non-catalytic subunit； AMP激活蛋白激酶β2(PRKAb2)； 腺苷单磷酸活化蛋白激酶β2；
背景信息：
PRKAB2 is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status and plays a role in protecting cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. AMPK is responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase (ACC). It also regulates cholesterol synthesis via phosphorylation and inactivation of hydroxymethylglutaryl-CoA reductase (HMGCR) and hormone-sensitive lipase. PRKAB2 may be a positive regulator of AMPK activity.
