基因名：
PRKAA2
产品别名：
AMPK； AMPK2； AMPKa2； PRKAA； PRKAA2； protein kinase AMP-activated catalytic subunit alpha 2； protein kinase AMP-activated catalytic subunit alpha 2； 5'-AMP-activated protein kinase catalytic subunit alpha-2； 5'-AMP-activated protein kinase, catalytic alpha-2 chain； ACACA kinase； AMPK alpha 2； AMPK subunit alpha-2； AMPK-alpha-2 chain； HMGCR kinase； acetyl-CoA carboxylase kinase； hydroxymethylglutaryl-CoA reductase kinase； protein kinase, AMP-activated, alpha 2 catalytic subunit； AMP激活蛋白激酶α2(PRKAa2)； 磷酸化腺苷单磷酸活化蛋白激酶α2； 腺苷单磷酸活化蛋白激酶α2；
背景信息：
The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia. [provided by RefSeq, Jul 2008]The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia. [provided by RefSeq, Jul 2008]
