基因名：
SRGN
产品别名：
PPG； PRG； PRG1； SRGN； serglycin； serglycin； serglycin； hematopoetic proteoglycan core peptide； hematopoetic proteoglycan core protein； hematopoietic proteoglycan core protein； p.PG； platelet proteoglycan core protein； proteoglycan 1, secretory granule； proteoglycan protein core for mast cell secretory granule； secretory granule proteoglycan core peptide； secretory granule proteoglycan core protein； serglycin proteoglycan； 丝甘蛋白聚糖(SRGN)； 硫酸软骨素多糖核心蛋白；
背景信息：
Plays a role in formation of mast cell secretory granules and mediates storage of various compounds in secretory vesicles. Required for storage of some proteases in both connective tissue and mucosal mast cells and for storage of granzyme B in T lymphocytes. Plays a role in localizing neutrophil elastase in azurophil granules of neutrophils. Mediates processing of MMP2. Plays a role in cytotoxic cell granule-mediated apoptosis by forming a complex with granzyme B which is delivered to cells by perforin to induce apoptosis. Regulates the secretion of TNF-alpha and may also regulate protease secretion. Inhibits bone mineralization.
