基因名：
PPP1R1A
产品别名：
I1； IPP1； PPP1R1A； protein phosphatase 1 regulatory inhibitor subunit 1A； protein phosphatase 1 regulatory inhibitor subunit 1A； protein phosphatase 1 regulatory subunit 1A； I-1； IPP-1； inhibitor-1； protein phosphatase inhibitor-1；
背景信息：
Protein Phosphatase 1 Regulatory Subunit 1A (PPP1R1A) is an inhibitor of protein-phosphatase 1. PPP1R1A is a cellular regulator of eIF2 alpha phosphorylation. In hormonal control of glycogen metabolism, IPP-1 protein plays important function. Hormones can elevate intracellular cAMP level and elevate IPP-1 activity. PPP1R1A activation caused cAMP increase , cAMP control over proteins that are not directly phosphorylated by PKA following a rise in intracellular calcium. IPP-1 is inactivated by calcineurin (PP2B). Multiple domains in IPP-1 target cellular PP1 complexes.
