基因名：
POU5F1
产品别名：
OCT3； OCT4； OTF-3； OTF3； OTF4； Oct-3； Oct-4； Oct3/4； POU5F1； POU class 5 homeobox 1； POU class 5 homeobox 1； POU domain, class 5, transcription factor 1； POU domain transcription factor OCT4； POU-type homeodomain-containing DNA-binding protein； octamer-binding protein 3； octamer-binding protein 4； octamer-binding transcription factor 3； 八聚体结合转录因子4(OCT4)； 胚胎干细胞关键蛋白； 胚胎干细胞关键蛋白190+O16161；
背景信息：
Expression of the POU-domain transcription factor Octamer-4 (Oct-4) is widely regarded as a hallmark of pluripotent stem cells. The relationship of Oct-4 to pluripotent stem cells is indicated by its tightly restricted expression to undifferentiated pluripotent stem cells. Upon differentiation to somatic lineages, the expression of Oct-4 disappears rapidly. Unlike the majority of pluripotent stem cell markers, the biological role of Oct-4 has been well characterized. Studies performed in mice point to the critical role of Oct-4 in the establishment and/or maintenance of pluripotent stem cells in an uncommitted state.
