基因名：
PMS2
产品别名：
HNPCC4； MLH4； MMRCS4； PMS-2； PMS2CL； PMSL2； PMS2； PMS1 homolog 2, mismatch repair system component； PMS1 homolog 2, mismatch repair system component； mismatch repair endonuclease PMS2； DNA mismatch repair protein PMS2； PMS1 homolog 2, mismatch repair protein； PMS1 protein homolog 2； PMS2 postmeiotic segregation increased 2； 肿瘤错配修复基因PMS2；
背景信息：
This gene is one of the PMS2 gene family members found in clusters on chromosome 7. The product of this gene is involved in DNA mismatch repair. It forms a heterodimer with MLH1 and this complex interacts with other complexes bound to mismatched bases. Mutations in this gene are associated with hereditary nonpolyposis colorectal cancer, Turcot syndrome, and are a cause of supratentorial primitive neuroectodermal tumors. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2008].
