重组磷脂酰肌醇激酶蛋白

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重组磷脂酰肌醇激酶蛋白

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

重组磷酸化磷脂酰肌醇激酶蛋白
Recombinant PIK3R1

基因名：

PIK3R1

产品别名：

AGM7； GRB1； IMD36； p85； p85-ALPHA； PIK3R1； phosphoinositide-3-kinase regulatory subunit 1； phosphoinositide-3-kinase regulatory subunit 1； phosphatidylinositol 3-kinase regulatory subunit alpha； PI3-kinase subunit p85-alpha； PI3K regulatory subunit alpha； phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha； phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)； phosphatidylinositol 3-kinase-associated p-85 alpha； phosphoinositide-3-kinase regulatory subunit alpha； phosphoinositide-3-kinase, regulatory subunit 1 (alpha)； ptdIns-3-kinase regulatory subunit alpha；磷脂酰肌醇激酶；磷酸化磷脂酰肌醇激酶；磷酸化磷脂酰肌醇激酶/PI3 Kinase P85α/γ；

背景信息：

The enzyme phosphatidylinositol 3 kinase (PI3 kinase) is a lipid kinase that generates phosphatidylinositol 3, 4, 5-triphosphate in response to receptor activation in many signal transduction pathways. Class IA PI3Ks exist as a heterodimer of a catalytic 110 kDa (p110) and a regulatory p85 subunit (e.g. p85 alpha). p85 alpha is an adaptor molecule that regulates the activity of the catalytic p110 subunit by binding to phosphorylated receptor tyrosine kinases (RTKs) through its SH2 domain and mediating the interaction between p110 and the plasma membrane. p85 alpha is necessary for insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues.