基因名:
SERPINI2
产品别名:
MEPI; PANCPIN; PI14; TSA2004; SERPINI2; serpin family I member 2; serpin family I member 2; serpin I2; myoepithelium-derived serine protease inhibitor; myoepithelium-derived serine proteinase inhibitor; pancreas-specific protein TSA2004; peptidase inhibitor 14; protease inhibitor 14; serine (or cysteine) proteinase inhibitor, clade I (neuroserpin), member 2; serine (or cysteine) proteinase inhibitor, clade I (pancpin), member 2; serpin peptidase inhibitor, clade I (pancpin), member 2; 蛋白酶抑制剂14;
背景信息:
SERPINI2 is a secreted protein of the serpin family. Serpins are a group of proteins with similar structures that were first identified as a set of proteins able to inhibit proteases. As protease inhibitors, serpins have an array of functions including regulating blood coagulation, fibrinolysis, the complement pathway, angiogenesis, inflammation, tumor suppression, extracellular matrix remodeling, and cell motility. SERPINI2 is expressed in human tissues including pancreas and adipose tissues. Mutations of human SERPINI2 can directly result in conditions such as acinar cell apoptosis and malabsorption.