基因名：
PDGFRA
产品别名：
CD140A； PDGFR-2； PDGFR2； PDGFRA； platelet derived growth factor receptor alpha； platelet derived growth factor receptor alpha； platelet-derived growth factor receptor alpha； CD140 antigen-like family member A； CD140a antigen； PDGF-R-alpha； alpha-type platelet-derived growth factor receptor； platelet-derived growth factor receptor 2； platelet-derived growth factor receptor, alpha polypeptide； PDGFRA蛋白； 磷酸化血小板源性生长因子受体-α； 磷酸化血小板源性生长因子受体α； 磷酸化血小板源性生长因子受体α/β； 血小板源性生长因子受体A/PDGFRα； 血小板衍生生长因子受体α(PDGFRa)；
背景信息：
Platelet-derived Growth Factor Receptor Alpha (PDGF Rα) is an enzyme that belongs to the class III subfamily of receptor tyrosine kinases.It is a type I transmembrane glycoprotein, and can form homo- or hetero-dimeric receptors when engaged by dimers of the PDGF family of growth factors, PDGF Rα is strongly expressed in oligodendrocyte, lung, skin and intestinal progenitor cells and induced by inflammation or growth in culture, but is lowly expressed in most mesenchymal cells. PDGF Rα autophosphorylates upon dimerization, activating signaling cascades in PI-3kinase Ras-MAP kinase, and PLC-γ pathways. PDGF Rα has infulence on local gradients of epithelially produced PDGF-AA or PDGF-CC during formation of the cranial ,cardiac neural crest and interstitial kidney mesenchyme.
