基因名：
PAFAH1B3
产品别名：
PAFAHG； PAFAH1B3； platelet activating factor acetylhydrolase 1b catalytic subunit 3； platelet activating factor acetylhydrolase 1b catalytic subunit 3； platelet-activating factor acetylhydrolase IB subunit alpha1； PAF acetylhydrolase 29 kDa subunit； PAF-AH 29 kDa subunit； PAF-AH subunit gamma； PAF-AH1b alpha 1 subunit； PAFAH subunit gamma； epididymis secretory sperm binding protein； platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)； platelet-activating factor acetylhydrolase IB subunit gamma； 血小板激活因子乙酰水解酶Ⅰb3(PAFAH1B3)； 血小板衍化生长因子γ；
背景信息：
The platelet activating factor (PAF) acetylhydrolases catalyze hydrolysis of the sn-2 ester bond of PAF and related pro-inflammatory phospholipids and thus attenuate their bioactivity. The family of PAF acetylhydrolases includes one secreted plasma isozyme and two intracellular isozymes. The intracellular isozymes are distinguished by differences in their primary sequence, tissue localization, subunit composition and substrate preferences. The most thoroughly characterized intracellular isoform, PAFAH1B, is a heterotrimeric protein expressed in brain tissue and plays and important role in brain development and function. PAFAH1B is comprised of a regulatory subunit (LIS1) and two homologous (63% identity) catalytic subunits (PAFAH1B2 and PAFAH1B3), which harbor all the activity of the enzyme. The PAFAH1B2 and PAFAH1B3 subunits readily associate with very high affinity to form heterodimers, and this dimerization is essential for both stability and catalytic activity. PAFAH1B3 is also commonly known as PAFAH1B 29kDa subunit, PAFAH1B subunit or PAFAH1B subunit α1.
