基因名：
NTRK1
产品别名：
MTC； TRK； TRK1； TRKA； Trk-A； p140-TrkA； NTRK1； neurotrophic receptor tyrosine kinase 1； neurotrophic receptor tyrosine kinase 1； high affinity nerve growth factor receptor； Oncogene TRK； TRK1-transforming tyrosine kinase protein； gp140trk； neurotrophic tyrosine kinase, receptor, type 1； tropomyosin-related kinase A； tyrosine kinase receptor A； 磷酸化酪氨酸激酶A； 磷酸化酪氨酸激酶受体A； 神经酪氨酸激酶受体1(NTRK1)； 酪氨酸激酶A； 酪氨酸激酶A/B/C； 酪氨酸激酶受体A；
背景信息：
This protein is a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date.
