基因名：
NF2
产品别名：
ACN； BANF； SCH； merlin-1； NF2； NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor； NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor； merlin； bilateral acoustic neurofibromatosis； moesin-ezrin-radixin like； moesin-ezrin-radixin-like protein； moesin-ezrin-radizin-like protein； neurofibromin 2 (bilateral acoustic neuroma)； neurofibromin-2； schwannomerlin； schwannomin； 2型神经纤维瘤； 磷酸化2型神经纤维瘤； 神经纤维素2(NF2)；
背景信息：
Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppresses cell proliferation and tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex.
