基因名：
NEK2
产品别名：
HsPK21； NEK2A； NLK1； PPP1R111； RP67； NEK2； NIMA related kinase 2； NIMA related kinase 2； serine/threonine-protein kinase Nek2； NIMA (never in mitosis gene a)-related kinase 2； nimA-like protein kinase 1； nimA-related protein kinase 2； protein phosphatase 1, regulatory subunit 111； 中心体相关蛋白激酶Nek2； 永离有丝分裂基因A相关激酶2(NEK2)；
背景信息：
Protein kinase that is involved in mitotic regulation. Integral component of the mitotic spindle-assembly checkpoint which is necessary for proper chromosome segregation during metaphase-anaphase transition. Required for association of MAD2L1 to kinetochore. Phosphorylates SGOL1. May have a role at the G2-M transition. May also play a role in meiosis. Isoform 1 but not isoform 2 appears to play a role in centrosome splitting. Isoform 1 phosphorylates and activates NEK11 in G1/S-arrested cells. Isoform 2, which is not present in the nucleolus, does not.
