基因名：
MYD88
产品别名：
IMD68； MYD88D； MYD88； MYD88 innate immune signal transduction adaptor； MYD88 innate immune signal transduction adaptor； myeloid differentiation primary response protein MyD88； TLR adaptor MYD88； mutant myeloid differentiation primary response 88； myeloid differentiation primary response 88； myeloid differentiation primary response gene (88)； 髓分化因子88(MyD88)； 髓样分化蛋白；
背景信息：
This gene encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways. These pathways regulate that activation of numerous proinflammatory genes. The encoded protein consists of an N-terminal death domain and a C-terminal Toll-interleukin1 receptor domain. Patients with defects in this gene have an increased susceptibility to pyogenic bacterial infections. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010].
