基因名:
MSX2
产品别名:
CRS2; FPP; HOX8; MSH; PFM; PFM1; MSX2; msh homeobox 2; msh homeobox 2; homeobox protein MSX-2; homeobox protein Hox-8; msh homeo box 2; msh homeobox homolog 2; 同源盒基因Msx2;
背景信息:
This gene encodes a member of the muscle segment homeobox gene family. The encoded protein is a transcriptional repressor whose normal activity may establish a balance between survival and apoptosis of neural crest-derived cells required for proper craniofacial morphogenesis. The encoded protein may also have a role in promoting cell growth under certain conditions and may be an important target for the RAS signaling pathways. Mutations in this gene are associated with parietal foramina 1 and craniosynostosis type 2. [provided by RefSeq, Jul 2008].