基因名:
MOG
产品别名:
BTN6; BTNL11; MOGIG2; NRCLP7; MOG; myelin oligodendrocyte glycoprotein; myelin oligodendrocyte glycoprotein; myelin-oligodendrocyte glycoprotein; MOG AluA; MOG AluB; MOG Ig-AluB; MOG alpha-5; 髓鞘少树突胶质细胞糖蛋白; 髓鞘少树突胶质细胞糖蛋白1-125; 髓鞘少突胶质细胞糖蛋白(MOG);
背景信息:
Myelin Oligodendrocyte Glycoprotein (MOG) is a transmembrane protein, which is expressed exclusively in the CNS. MOG contains a single Ig-domain exposed to the extracellular space that allows autoantibodies easy access. MOG protein has been identified as a crucial autoantigen for multiple sclerosis in humans. MOG is capable to produce a demyelinating multiple sclerosis-like diseases in experimental animals, namely experimental autoimmune encephalomyelitis (EAE), in rodents and monkeys.