基因名：
MGMT
产品别名：
MGMT； O-6-methylguanine-DNA methyltransferase； O-6-methylguanine-DNA methyltransferase； methylated-DNA--protein-cysteine methyltransferase； 6-O-methylguanine-DNA methyltransferase； O-6-methylguanine-DNA-alkyltransferase； O6-methylguanine-DNA methyltransferase； methylguanine-DNA methyltransferase； O-6-甲基鸟嘌呤DNA甲基转移酶(MGMT)； O6甲基鸟嘌呤DNA甲基转移酶；
背景信息：
MGMT belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. MGMT involved in the cellular defense against the biological effects of O6-methylguanine in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. MGMT catalyzes the chemical reaction: DNA (containing 6-O-methylguanine) and proteinL-cysteine into DNA (without 6-O-methylguanine) and protein S-methyl-L-cysteine.
