基因名：
MFGE8
产品别名：
BA46； EDIL1； HMFG； HsT19888； MFG-E8； MFGM； OAcGD3S； SED1； SPAG10； hP47； MFGE8； milk fat globule EGF and factor V/VIII domain containing； milk fat globule EGF and factor V/VIII domain containing； lactadherin； O-acetyl disialoganglioside synthase； breast epithelial antigen BA46； medin； milk fat globule-EGF factor 8 protein； sperm associated antigen 10； sperm surface protein hP47； 乳脂球表皮生长因子8(MFGE8)； 乳腺上皮细胞抗原BA46；
背景信息：
MFG-E8, also known as lactadherin and MFGE8, contains 1 EGF-like domain and 2 F5/8 type C domains. It also contains phosphatidylserine (PS) binding domain, as well as an Arginine-Glycine-Aspartic acid motif, which enables the binding to integrins. It binds PS, which is exposed on the surface of apoptotic cells. MFG-E8 is expressed in mammary epithelial cell surfaces and aortic media. Overexpression of MFG-E8 can be found in several carcinomas. MFG-E8 has opsonization of the apoptotic cells and binding to integrins on the surface of phagocytic cells. It also mediates the engulfment of the dead cell. MFG-E8 plays an important role in the maintenance of intestinal epithelial homeostasis and the promotion of mucosal healing. It promotes VEGF-dependent neovascularization and contributes to the phagocytic removal of apoptotic cells in many tissues. It also binds to phosphatidylserine-enriched cell surfaces in a receptor-independent manner.
