基因名：
MEP1B
产品别名：
MEP1B； meprin A subunit beta； meprin A subunit beta； meprin A subunit beta； N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit beta； N-benzoyl-L-tyrosyl-p-amino-benzoic acid hydrolase beta subunit； PABA peptide hydrolase； PPH beta； endopeptidase-2； meprin A, beta； meprin B； 安眠蛋白1β(MEP1b)； 苯甲酸肽水解酶β；
背景信息：
Meprins are multidomain zinc metalloproteases that are highly expressed in mammalian kidney and intestinal brush border membranes, and in leukocytes and certain cancer cells. They are involved in the hydrolysis of a variety of peptide and protein substrates, and have been implicated in cancer and intestinal inflammation. Mature meprins are oligomers of evolutionarily related, but separately encoded alpha and/or beta subunits. Homooligomers of alpha subunit are secreted, whereas, oligomers containing the beta subunit are plasma membrane-bound. This gene encodes the beta subunit. Targeted disruption of this gene in mice affects embryonic viability, renal gene expression profiles, and distribution of the membrane-associated alpha subunit in kidney and intestine. [provided by RefSeq, Oct 2011]
